مرکز منطقه ای اطلاع رساني علوم و فناوري - Quorum Sensing Inhibitory Activities of Alpha-Pinene, Terpineol, Cineole, Linalool and Camphor

Abstract :

Many pathogenic Gram negative bacteria often use N-Acyl homoserine lactone mediated cell to cell communication (quorum sensing) system to control the gene expression of various virulence factors. Thus blocking or manipulating this system makes it an attractive target for discovery of new therapeutics. There are a number of plant-based natural products as quorum sensing inhibitors.. In this study, QS inhibitory potential of laurus, salvia, myrtus and juniperus essential oils were screened and compositions of oils were analysed by GC-MS. The anti-quorum sensing activity of alpha pinene, terpineol, cineole, linalool and camphor (major components of oils) tested against using Chromobacterium violaceum strain CV026, C. violaceum strain VIR07, Pseudomonas aeruginosa PAO1, P. aeruginosa PAC-1. Results showed that alpha pinene, terpineol, cineole, linalool and camphor significantly inhibited violacein production in C. violaceum 026, C. violaceum VIR07, as well as the elastase, pyocyanin production, swarming motilty in P. aeruginosa PAO1, P. aeruginosa PAC-1. Our findings demonstrated that alpha pinene, terpineol, cineole, linalool and camphor have potential as inhibitors of quorum sensing system in C violaceum and P. aeruginosa.