مرکز منطقه ای اطلاع رساني علوم و فناوري - CHRONIC INFLAMMATION MARKERS hs-CRP, sICAM-1, sVCAM-1 AND sE-SELECTIN LEVELS IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME

Abstract :

Objective: Patients with polycystic ovary syndrome have many risk factors associated with development of cardiovascular disease development. Presence of low grade chronic inflammation has been indicated as a risk factor for cardiovascular disease. We investigated the levels of hs-CRP, sICAM-1, sVCAM-1 and sE-Selektin as markers of chronic inflammation.Materials and methods: 40 women with diagnosis of PCOS (Polycystic ovary syndrome) according to Rotterdam 2003 PCOS defining criteria and 39 premenauposal otherwise healthy women taken as a control group were included in the study. Insulin resistance was estimated by fasting glucose/insulin ratio and HOMA index. Plasma hs-CRP, sICAM-1, sVCAM-1 and sE-selektin levels were determined by sandwich ELISA method. Mann Whitney U and spearman‟s correlation tests were used statistics. Results: Insulin resistance was deteced in 40% of patients with polycystic ovary syndrome.When compared wih control patients total cholesterol (p 0.05), VLDL (p 0.0001) and triglyceride (p 0.01) were higher in patients with PCOS. There were no significant differences in the levels the LDL and HDL. The levels of hs-CRP (p 0.001), sICAM-1 (p 0.001) and sE-selectin (p 0.0001) in patients with PCOS were higher than control group but there was no difference in sVCAM-1 levels between the groups. There was positive correlation according to Spearman‟s test between hs-CRP/sICAM-1 (r=0.251; p 0.05) and sE-selektin/sICAM-1 (r=0.317; p 0.05). Conclusion In patients with PCOS the presence of chronic low grade inflammation which is a risk factor for endothelial dysfunction hence cardiovascular disease is demonstrated. But there is yet no prospective randomised study dealing with mortality due to cardiovascular disease in patients with PCOS.