Author/Authors :
BALCI, Hatice Cumhuriyet Üniversitesi - Diş Hekimliği Fakültesi - Periodontoloji Anabilim Dalı, Turkey , TOKER, Hülya Cumhuriyet Üniversitesi - Diş Hekimliği Fakültesi - Periodontoloji Anabilim Dalı, Turkey
Abstract :
Platelet-rich fibrin was first described by Choukroun et al. in France. It has been referred to as a second-generation platelet concentrate, which has been shown to have several advantages over traditionally prepared PRP. This article describes properties, composition, preparation and uses of PRF. All blood components are available in PRF. These are, growth factors such as; Platelet-derived growth factor (PDGF), Vascular endothelial growth factor (VEGF), Insulin-like growth factor (IGF), Transforming growth factor-β (TGF-β), cytokines such as; IL-1β, IL-4, IL-6 and tumor necrosis factor-α (TNF-α), cell components like platelets and neutrophils and fibrin. It’s chief advantages include ease of preparation, low cost and lack of biochemical handling of harvested blood. Greatest differance from other platelet concentrates is that slow polimerisation in PRF process allows occuring of naturally like fibrin. This fibrin mess allows more potent cell migration, proliferation and tissue healing.
NaturalLanguageKeyword :
Platelet , rich fibrin , wound healing , growth factors
