Author/Authors :
Kaya, Mehmet Istanbul Üniversitesi - Istanbul Tip Fakültesi - Fizyoloji Anabilim Dali, Turkey , Çevik, Aydin Deneysel Tip Arastirma Enstitüsü - Deney Hayvanlari Biyolojisi ve Biyomedikal Uygulama Teknikleri Anabilim Dali, Turkey
Abstract :
The purpose of animal studies is to understand the physiologic and pathologic mechanisms at the level of ceU/tissue/organ/tissue, to learn the systems and relations between various systems, to develop novel treatments against diseases, to develop novel diagnostic measures for diseases and/or disorders, to contribute to the education of scientists and physicians of the future. There are many similarities between humans and animals. These similarities in immune system; Human-Mouse; similarities in cardiovascular function: Human-Dog; poliomyelitis: Monkey-test in humans. Banting and Best have shown the impact of insulin in dogs in diabetes studies. Obesity: Leptin research in Mouse and Zucker obese rat models; hypertension treatment modalities by research in rats, cats and dogs; infant deaths; hyaline membrane disease was shown to be the leading cause of death in preterm infants by studies in sheep/lambs. Gene therapy approaches are being tested in mouse models. Alternatives before choosing the appropriate animal model non-animal models. Animal model should be considered only if it is inevitable. Experiments consist of demonstrating the application of the effects of parameters organized at various levels and of obtaining the results on the animals. First of all, true experimental design should be done. During the study, it requires to consider the starting of real experiment/Data recruitment and processing. It is also necessity the interpretation of data, completion and submission of outputs, completion of administrative affairs, interpretation of experiences and taking lessons. Therefore, sharing the results with the scientific world is also required.
