Küçükhüseyin, Özlem Istanbul Üniversitesi - Deneysel Tip Arastirma Enstitüsü - Moleküler Tip Anabilim Dali, Turkey , Öztürk, Oguz Istanbul Üniversitesi - Deneysel Tip Arastirma Enstitüsü - Moleküler Tip Anabilim Dali, Turkey

Micrornas and Their Roles in Breast Cancer

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In recent years studies are accelerated in determining the possible molecular mechanisms of breast cancer in addition to the development of many treatment strategies. However these treatment strategies cause different curative responses and/or development of adjuvant therapy resistance in breast cancer patients. On the other hand, with more recent studies declaring the roles of miRNAs as the regulators of gene expression miRNAs became new potential therapeutic targets and thus evaluated as candidate diagnostic and prognostic indicators of breast cancer. Eventually it was expected that in near future miRNAs have parts in both tumor classification and efficient treatment strategies as novel biomarkers and prognostic indicators as well as in the classification of breast cancer according to tumor gene expression markers. İn addition it was thought that creating of miRNA expression models could explain the molecular basis of the subtypes and also could contribute to the development of targeted treatment models. Thus the biological roles of miRNAs in several diseases and effective mechanisms in breast cancers will be discussed in this review.

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Deneysel Tıp Araştırma Enstitüsü Dergisidir

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