Author/Authors :
Cacına, Canan İstanbul Üniversitesi - Deneysel Tıp Araştırma Enstitüsü (DETAE) - Moleküler Tıp Anabilim Dalı, Turkey , Yaylım, İlhan İstanbul Üniversitesi - Deneysel Tıp Araştırma Enstitüsü (DETAE) - Moleküler Tıp Anabilim Dalı, Turkey
Title Of Article :
Gastric Cancer and Epidermal Growth Factor Signal Transduction Pathway
Abstract :
Gastric cancer is the more common type of cancer in the world. Although the etiology of gastric cancer is not well-understood, nutritional, microbial, and genetic factors playing important roles and multifactorial process have been suggested. Epidermal growth factor (EGF) play important roles in several signaling pathways, leading to proliferation, differentiation, and it is the natural ligand of the epidermal growth factor receptor (EGFR) which is the member of tyrosine kinase transmembrane receptor family. EGF and epidermal growth factor receptor regulate important processes in tumorogenesis, including ceU survival, cell cycle progression and irregulation in the this signaling pathway is frequently observed in some of the type of cancer. We are of the opinion that current review may offer an insight into the other studies which will analyse the importance molecular aspect of this area.
NaturalLanguageKeyword :
Gastric Cancer , Cell Cycle , Epidermal Growth Factor
JournalTitle :
Deneysel Tıp Araştırma Enstitüsü Dergisidir
