Author/Authors :
Kıskaç, Muharrem Okmeydanı Eğitim Araştırma Hastanesi - İç Hastalıkları Kliniği, Turkey , Helvacı, Ayşen Okmeydanı Eğitim Araştırma Hastanesi - İç Hastalıkları Kliniği, Turkey , Zorlu, Mehmet Okmeydanı Eğitim Araştırma Hastanesi - İç Hastalıkları Kliniği, Turkey , Yolbaş, Servet Okmeydanı Eğitim Araştırma Hastanesi - İç Hastalıkları Kliniği, Turkey , Oran, Mustafa Cerrahpaşa Tıp Fakültesi - İç Hastalıkları Anabilim Dalı, Turkey , Ardıç, Cüneyt Haseki Eğitim Araştırma Hastanesi - Aile Hekimliği, Turkey , Adaş, Mine Okmeydanı Eğitim Araştırma Hastanesi - İç Hastalıkları Kliniği, Turkey
Abstract :
Objectives: The aim of this study was to investigate the relationship between subclinical hypothyroid and QTc dispersion indicating local heterogeneity in repolarization of myocardium, which is well known as independent cardiac risk factor for sudden death and ventricular arrhythmia.Materials and Methods: We compared QTc dispersion of subclinical hypothyroid patients, after treatment and healthy control group. We included a total of 50 patients with 41 women and 9 men in the study group. Electrocardiography with 12 derivations, thyroid hormones, serum electrolytes and basic biochemical parameters were measured. The control group consisted of 25 healthy individuals. QT distances were calculated by using Bazet formula. The difference between the longest QTc and the shortest QTc distance was accepted as QTc dispersion (QTcd).Results: Comparison of subclinical hypothyroid patients, their euthyroidic period after treatment and healthy control group, gave no significant differences in age, body weight, body mass index and free thyroxin values. However, significant difference was found in durations of QTd and QTcd between the subclinical hypothyroid, the control and the euthyroidic groups (p 0.001). No significant differences were found in QTc and QTcd durations between euthyroidic period and healthy subjects (p 0.05).Conclusion: Our results suggested that subclinical hypothyroid patients had longer QTc dispersion compared to euthyroidic period and healthy subjects. However there was no QTcd difference between the euthyroidic period and healthy control group.
