Jain, Suksham Government Medical College Hospital - Department of Pediatrics, India , Chawla, Deepak Government Medical College Hospital - Department of Pediatrics, India

Transient hyperammonemia of newborn

26374

Transient hyperammonemia of neonate (THAN) presents within first few days of postnatal life in form of severe hyperammonemia, a comatose state, absence of abnormal organic aciduria, normal activity of urea cycle enzymes and usually, completes recovery. In contrast to some of the hereditary disorders of the urea cycle, no specific structural changes could be found in THAN in liver.We herein reported a neonate with THAN presented with episode of a generalized clonic seizure of 10-15 secondds duration followed by respiratory failure needing mechanical ventilation.

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Child , neonate , transient hyperammonemia , diagnosis

Dicle Medical Journal

306