Author/Authors :
Hanımeli, Özlem Aktaş Celal Bayar Üniversitesi - Tıp Fakültesi - Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Turkey , Yılmaz, Özge Celal Bayar Üniversitesi - Tıp Fakültesi - Pediatrik Alerji Bilim Dalı, Solunum Birimi, Turkey , Yüksel, Hasan Celal Bayar Üniversitesi - Tıp Fakültesi - Pediatrik Alerji Bilim Dalı, Solunum Birimi, Turkey
Title Of Article :
Approach to a child with primary immunodeficiency
Abstract :
Primary immunodeficiencies are clinically and epidemiologically important, despite their low prevalence, due to the associated risk of high morbidity and mortality. Most commonly encountered primary immunodeficiencies include humoral immune system deficiencies, cellular immune system defects, combined immunodeficiencies, phagocyte system defects, complement system defects. Classical clinical findings of immunodeficiencies include recurrent, severe infections which do not respond to treatment or which progress with complications as well as tendency to develop infections with low virulence microorganisms. Moreover, they may present with autoimmunity, autoinflammatory or hemaphagocytic syndromes. Congenital diseases usually start in early childhood and lead to morbidity and mortality. Therefore, early diagnosis may be life saving and allow increasing quality of life, genetic counseling or prenatal diagnosis. Considering primary immunodeficiencies more frequently in differential diagnosis and early immunological evaluation would lead to early diagnosis of these patients and allow them to reach early treatment or preventive measures.
NaturalLanguageKeyword :
Primary immunodeficiencies , clinical evaluation , children
JournalTitle :
Dicle Medical Journal
