Güngör, Adem Düzce Üniversitesi - Tıp Fakültesi - İç Hastalıkları A D, Turkey , Aydın, Yusuf Düzce Üniversitesi - Tıp Fakültesi - İç Hastalıkları, Endokrinoloji ve Metabolizma B D, Turkey , Celbek, Gökhan Düzce Üniversitesi - Tıp Fakültesi - İç Hastalıkları A D, Turkey , Başar, Cengiz Düzce Üniversitesi - Tıp Fakültesi - Kardiyoloji A D, Turkey , Alemdar, Recai Düzce Üniversitesi - Tıp Fakültesi - Kardiyoloji A D, Turkey , Ordu, Serkan Düzce Üniversitesi - Tıp Fakültesi - Kardiyoloji A D, Turkey , Yıldırım, Hayriye Ak Düzce Üniversitesi - Tıp Fakültesi - Biyokimya A D, Turkey , Özhan, Hakan Düzce Üniversitesi - Tıp Fakültesi - Kardiyoloji A D, Turkey

Asymmetric dimethylarginine levels in dipper and nondipper hypertensive patients

26400

Objectives: Asymmetric Dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthesis and also is an indicator of endothelial dysfunction. Patients who have nondipper blood pressure pattern have been shown to exhibit more endothelial dysfunction than patients who has dipper blood pressure pattern. However, other endogenous markers, but not ADMA, are used to assess endothelial function in these studies. In our study, we used ADMA levels to compare differences in endothelial function between each groups. Materials and methods: This study includes 87 patients who admitted to Düzce University internal medicine and Cardiology outpatient clinics throughout 6 months and have been diagnosed previously as essential hypertension and followed with medical therapy. Patients were divided into two groups as non-dippers and dippers, using ambulatory blood pressure measurement. Patients’ body mass index, Systolic blood pressure and diastolic blood pressure, triglycerides, total cholesterol, low density lipoprotein (LDL) cholesterol, high density lipoprotein (HDL) cholesterol, and ADMA levels were measured. Results: Age, BMI, and lipid values did not differ significantly between groups (p 0.05). Mean ADMA level was 1.29±0.13 in dippers, and that of non-dippers was 1.27±0.13μmol/L. ADMA levels did not differ significantly between the non-dipper and dipper groups (p=0.575). Conclusion: ADMA levels were found to be higher in hypertensive patients due to endothelial dysfunction. Endothelial dysfunction was more frequent in patients who had nondipper blood pressure pattern than patients who had dipper blood pressure pattern. In our study, ADMA levels did not differ significantly between two patterns.

332

Dipper , Hypertension , Non , Dipper , Hypertension , ADMA

Dicle Medical Journal

338