Author/Authors :
Aydın, Yusuf Keçiören Eğitim ve Araştırma Hastanesi - Aile Hekimliği Birimi, Turkey , Nazlıgül, Yaşar Keçiören Eğitim ve Araştırma Hastanesi - Gastroenteroloji Kliniği, Turkey , Yeniova, Abdullah Ö. Keçiören Eğitim ve Araştırma Hastanesi - Gastroenteroloji Kliniği, Turkey , Kefeli, Ayşe Keçiören Eğitim ve Araştırma Hastanesi - Gastroenteroloji Kliniği, Turkey , Şimşek, Gülçin Keçiören Eğitim ve Araştırma Hastanesi - Patoloji Laboratuvarı, Turkey , Saçıkara, Muhammed Keçiören Eğitim ve Araştırma Hastanesi - Dahiliye Kliniği, Turkey , Polat, Mehmet Keçiören Eğitim ve Araştırma Hastanesi - Dahiliye Kliniği, Turkey , Akkuş, İbrahim Halil Keçiören Eğitim ve Araştırma Hastanesi - Aile Hekimliği Birimi, Turkey
Abstract :
Objectives: Standard triple therapy composed of a proton pump inhibitor, clarithromycin and amoxicillin has been widely preferred for H. pylori eradication in Turkey and World. Alternative therapies are currently under investigation because of an increase in clarithromycin resistance. The aim of this study was to evaluate the efficacy of a levoflox-acin-containing triple therapy.Materials and methods: The study was carried out in 81 H. pylori-infected patients (52 female, 29 male) with nonul-cer dyspepsia. The mean age was found 46.3 ± 13.9. Treatment was indicated with lansoprazol 30 mg b.d., amoxicil-lin 1 g b.d., and levofloxacin 500 mg daily for 7 days. H. pylori status was rechecked by (14)C urea breath test 6-8 weeks after the end of therapy.Results: Totally 81 patients could complete the treatment and follow-up protocol. Effectiveness was 68%. The distrib-tions of age, gender and smoking were similar between eradicated and non-eradicated groups (p 0.05).Conclusion: Seven-day levofloxacin based triple therapy is not very effective in the first-line treatment of H. pylori in-fection. The new treatment modalities should be investigated.
NaturalLanguageKeyword :
Levofloxacin , Helicobacter pylori , first , line therapy.
