Özekinci, Tuncer University of Dicle - Faculty of Medicine - Deparment of Microbiology, Turkey , Atmaca, Selahattin University of Dicle - Faculty of Medicine - Deparment of Microbiology, Turkey , Akbayın, Hasan University of Dicle - Faculty of Education, Turkey

Correlation of high sensitive C-reactive protein and Hepatitis C Virus RNA in anti-HCV-positive sera

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Objectives: To determine whether the level of high sensitive C-reactive protein (hsCRP) secreted from liver differed according to the positivity and negativity of the HCV RNA in sera collected from individuals with HCV antibodies.Materials and methods: A total of 84 patients with clinically suspected Hepatitis C were included in this study, in which anti-HCV was detected to be positive. Eighty four anti-HCV positive samples were divided into two groups according to the HCV RNA results, as the HCV RNA positive group (Group 1, 50 samples) and the HCV RNA negative group (Group 2, 34 samples).Results: 50 of the 84 samples with anti HCV positivity were detected to be positive for HCV RNA (Group 1), whereas 30 were detected as negative (Group 2). While the hsCRP values were found to be above the normal level in 11 (22%) of the 50 sera samples in the first group, and in 3 (8,8%) of the 34 sera samples in the second group.Conclusion: Numerical comparison of the hsCRP positive samples revealed a statistically significant result in favor of group 1 (p 0,001). On the other hand, results obtained from comparison of the quantitative hsCRP mean values obtained from the two groups were found to be statistically insignificant (P 0.05).

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HCV , hsCRP , correlation

Dicle Medical Journal

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