Keleş, Ayşenur Dicle Üniversitesi - Tıp Fakültesi - Patoloji Anabilim Dalı, Turkey , Gönül, İpek Işık Gazi Üniversitesi - Tıp Fakültesi - Patoloji Anabilim Dalı, Turkey , Fırat, Uğur Dicle Üniversitesi - Tıp Fakültesi - Patoloji Anabilim Dalı, Turkey , Küçüköner, Mehmet Dicle Üniversitesi - Tıp Fakültesi - Onkoloji Bilim Dalı, Turkey

An epidemiologic study on urothelial carcinomas of bladder

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Objectives: In this study, the epidemiological analysis of the bladder cancers was performed accompanied by the known environmental factors.Materials and methods: In this retrospective study, pathology archival materials of 420 patients (350 men (83.4%) and 70 women (16.6%)), consisting of bladder by transurethral resection, cystectomy and cystoprostatectomy specimens, histopathologically diagnosed as urothelial carcinoma and papillary urothelial neoplasia with low malignant potential, were included. For bladder carcinomas, the parameters such as tumor types, age, sex, and invasiveness of tumor were evaluated and analyzed.Results: In the study, it was found that 24.7% of papillary urothelial neoplasia with low malignant potential, 46.1% of low-grade urothelial carcinoma, and 29.0% of high grade urothelial carcinoma. The rate of bladder urothelial carcinomas was 5 times greater in men than in women. In addition, the high-grade papillary urothelial carcinoma was seen more frequently in men than in women (31.2% and 23.1% respectively), while low-grade papillary urothelial carcinoma was seen more frequently in women than in men (32.9% and 18.5% respectively) (p 0.05).Conclusion: The bladder urothelial carcinoma was more common in men than women, and high-grade urothelial carcinoma invading the lamina propria and the muscularis propria also found in a higher ratio in male. Further clinical and experimental studies are needed to explore the cause of high frequency of high-grade types in male gender.

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Bladder , urothelial carcinoma , epidemiology

Dicle Medical Journal

334