Author/Authors :
Can, Nuray Şanlıurfa Education and Research Hospital - Department of Pathology, Turkey , Puyan, Fulya Öz Trakya University - Medical Faculty - Department of Pathology, Turkey , Öz, Feriha German Hospital - Department of Pathology, Turkey , Özyılmaz, Filiz Trakya University - Medical Faculty - Department of Pathology, Turkey , Altaner, Şemsi Trakya University - Medical Faculty - Department of Pathology, Turkey , Pehlivanoğlu, Zeynep Trakya University - Medical Faculty - Department of Pathology, Turkey , Kutlu, A. Kemal Trakya University - Medical Faculty - Department of Pathology, Turkey
Abstract :
Warthin-like papillary thyroid carcinoma is a rare variant of papillary thyroid carcinoma with favorable prognosis. The tumor is named “Warthin-like papillary thyroid carcinoma” because of bearing a striking morphological resemblance to Warthin’s tumor occurring in the salivary glands. Thyroid ultrasonography of 65 years old female patient with a history of bilateral subtotal thyroidectomy 30 years ago in another center with unknown histopathological diagnosis revealed a 20 mm isoechoic solid nodule in the left lobe and this nodule was hypoactive in thyroid scintigraphy. Grossly, a grey-tan colored, solid nodule with 1 cm diameter was seen in the left lobe. Histologically, the tumor was composed of papillary structures surrounded by marked lymphocytic stroma and oncocytic cells with papillary carcinoma’s nuclear features were lining the papillae. Hashimoto’s thyroiditis was present throughout the thyroid. Immunohistochemically, tumor cells exhibited cytokeratin 19, Thyroid transcription factor-1 (TTF-1), Galectin-3, HBME-1(Mesothelioma antibody) and thyroglobulin positivity, proliferative index with Ki-67 was low. Warthin-like papillary thyroid carcinoma is a rare variant of papillary thyroid carcinoma and other oncocytic cell lesions especially Hurthle cell carcinoma should be kept in mind in the differential diagnosis of this neoplasm.
NaturalLanguageKeyword :
Thyroid , carcinoma , Warthin , like tumor
