Kutlucan, Ali Düzce University - Faculty of Medicine - Department of Internal Medicine, TURKEY , Tunc, Sevket Ercan Suleyman Demirel University - Faculty of Medicine - Department of Internal Medicine, Division of Rheumatology, Turkey , Baltacı, Davut Düzce University - Medical Faculty - Department of Family Medicine, Turkey , Sahin, Mehmet Suleyman Demirel University - Faculty of Medicine - Department of Internal Medicine, Division of Rheumatology, Turkey , Ozsahin, Mustafa Duzce University - Faculty of Medicine - Department of Physical Medicine and Rehabilitation, Turkey , Sütcü, Recep Suleyman Demirel University - Faculty of Medicine - Department of Biochemistry, Turkey , Ermis, Fatih Duzce University - Faculty of Medicine - Department of Internal Medicine, Turkey , Süslü, Harun Suleyman Demirel University - Faculty of Medicine - Department of Nuclear Medicine, Turkey

Serum levels of TNF-α and osteoprotegerin and bone mineral density in patients with Behçet’s Disease

26605

Objectives: Osteoporosis is commonly developed due to natural course of Behçet’s disease (BD) and therapeutic agents. It was aimed to investigate levels of osteoprotegerin and TNF-α (tumor necrosis factor), and bone mineral density (BMD) and correlation between them in BD. Materials and methods: The study included two groups as the study and the control group. Serum levels of TNF-α, osteoprotegerin, osteocalcine, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and urinary creatinine and deoxypyridinoline along with BMD level were evaluated and compared. Correlation between TNF-α and osteoprotegerin level was investigated. Results: The study enrolled 41 BD patients and 36 aged-matched control subjects. Mean age was 42.26±11.64 and 41.66±70.99, in the study and control groups, respectively. There was no significant difference in body mass index (BMI) of subjects between groups (p 0.05). Level of TNF-α (p 0.001), deoxypyridinoline (p 0.001) and osteocalcine (p=0.041) was significantly higher in the study group compared to the control group. Osteoprotegerin was lower in BD patients, but the difference was not significant (p 0.05). Urinary deoxypyridinoline/ urinary creatinine ratio in patients with BD was significantly higher than those in control group (p=0.030). Patients had significantly lower BMD comparfed to the control group, except L2-L4 vertebral area (p 0.001, p 0.001, p=0.035, p 0.001, p=0.012, p 0.001, p 0.001 and p=0.111, respectively). No correlation was found between TNF-α and osteoprotegerin. Conclusions: The present study indicated that TNF-α and BMD was negatively correlated with each other and TNF-α had an effect on osteoporotic process in patients with BD. Osteoprotegerin level was not decreased, and not correlated with TNF-α.

325

Behçet’s disease , osteoprotegerin , TNF , α , osteocalcine

Dicle Medical Journal

330