Elastic properties of the aorta and factors affecting aortic stiffness in patients with metabolic syndrome

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Objectives: In this study, we evaluated aortic stiffness and echocardiographic and laboratory factors affecting aortic stiffness in patients with metabolic syndrome (MetS). Materials and methods: Forty-six patients (25 male, mean age 47.3±6.5 years) with the diagnosis of MetS according to the Adult Treatment Panel III Final Report criteria were included. Forty-four age and gender matched healthy subjects (18 male, mean age 46.0±6.1 years) were recruited as the control group. Aortic strain, distensibility and stiffness index were calculated by M-mode echocardiography and diastolic parameters were measured. Results: Left ventricular mass index (LVMI), deceleration time (DT), isovolumic relaxation time (IVRT) were increased and mitral E/A ratio was decreased in patients with MetS compared to controls. In the MetS patients, aortic distensibility was significantly decreased (10.4±3.5 cm2.dyn-1.10-6 vs. 12.7±3.4 cm2.dyn-1.10-6, p=0.002), and ASI was significantly increased (6.5±2.0 vs. 3.2±0.8, p 0.001). ASI was positively correlated with triglycerides, fasting glucose, uric acid, hsCRP, LVMI, DT, IVRT and systolic blood pressure level, and was negatively correlated with HDL-cholesterol and mitral E/A ratio. In regres-sion analysis, hsCRP (p=0.05) and systolic blood pressure level (p 0.001) were independent predictors of ASI. Conclusions: ASI is increased in patients with MetS. In these patients; decrease in aortic elasticity properties was associated with left ventricular diastolic dysfunction. High systolic pressure and hsCRP levels were found to be independent predictors of ASI.

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Metabolic syndrome , Echocardiography , elastic properties of aorta , hsCRP

Dicle Medical Journal

370

Dicle Medical Journal