Author/Authors :
Çakırca, Gökhan Ceylanpınar State Hospital - Department of Biochemistry, Turkey , Mete, Nuriye Dicle University - Faculty of Medicine - Department of Biochemistry, Turkey , Batmaz, Ibrahim Dicle University - Faculty of Medicine - Dept Physical Medicine and Rehabilitation, Turkey , Sarıyıldız, Mustafa Akif Dicle University - Faculty of Medicine - Dept Physical Medicine and Rehabilitation, Turkey , Ulu, Mehmet Ali Batman State Hospital - Dept , Physical Medicine and Rehabilitation, Turkey , Yazmalar, Levent Dicle University - Faculty of Medicine - Dept Physical Medicine and Rehabilitation, Turkey , Celepkolu, Tahsin Dicle University - Faculty of Medicine - Dept , Family Medicine, Turkey , Çevik, Remzi Dicle University - Faculty of Medicine - Dept Physical Medicine and Rehabilitation, Turkey
Abstract :
Objectives: The aim of this study was to evaluate the levels of osteoprotegerin (OPG), nuclear factor kappa B receptor activator ligand (RANKL), cathepsin K in patients with rheumatoid arthritis (RA) and the relation between these parameters and bone mineral density (BMD). Materials and methods: Totally 90 cases including 30 postmenopausal and healthy women, 30 with postmenopausal osteoporosis and 30 with postmenopause RA were enrolled in the study. The serum RANKL, OPG and cathepsin K were measured by ELISA method. Results: The levels of serum RANKL and OPG in the patients with postmenopausal RA were found significantly higher compared to the postmenopausal healthy women whereas the rate of serum OPG/RANKL was found significantly lower. In addition, the rate of OPG and OPG/ RANKL were significantly lower in patients with postmenopausal RA compared to the postmenopausal osteoporosis, whereas the level of serum RANKL was significantly higher. Positive correlation was detected between bone densities of lumbar spine (LS), femur neck (FN) and the rate of OPG/RANKL in patients with postmenopausal RA. Also negative correlation was detected between LS and FN bone densities and RANKL levels. Conclusions: The system of RANKL/RANK/OPG may have a role in osteoporosis and RA pathogenesis and the rate of OPG/RANKL might be a significant determiner of bone density.
NaturalLanguageKeyword :
Osteoporosis , rheumatoid arthritis , RANKL , OPG , cathepsin , K
