Author/Authors
Uluca, Ünal Dicle Üniversitesi - Tıp Fakültesi - Çocuk Hastalıkları Anabilim Dalı, Türkiye , Keskin, Özlem Gaziantep Üniversitesi - Tıp Fakültesi - Çocuk Astım ve Allerji BD, Türkiye , Gögebakan, Bülent Mustafa Kemal Üniversitesi - Tıp Fakültesi - Tıbbi Biyoloji AD, Türkiye , Balaban, Sinan Şanlıurfa Kadın Hastalıkları ve Doğum Hastanesi Yenidoğan - Yoğun Bakım Ünitesi, Türkiye , Keskin, Mehmet Gaziantep Üniversitesi - Tıp Fakültesi - Çocuk Endokrinoloji BD, Türkiye , Küçükosmanoğlu, Ercan Dicle Üniversitesi - Tıp Fakültesi - Çocuk Sağlığı ve Hastalıkları AD, Türkiye
Title Of Article
The comparison of early and late effectiveness of systemic and high dose inhaled glucocorticoids in the management of acute asthma attacks in children
شماره ركورد
26673
Abstract
Objective: In this study it was aimed to compare effectiveness of systemic steroids and inhaled corticosteroids in children who applied with acute asthmatic attack. Materials and methods: Children with acute asthmatic attack were randomly allocated to two groups; 1 mg/kg per oral methylprednisolone was given to Group 1 (Systemic steroid group, n=27), and 4000 μg inhaled fluticasone to Group 2 (Inhaled steroid group, n=35). Following treatment patients were evaluated for four hours, at one-hour intervals by asthma score, forced expiratory volume in first-second (FEV1) and peak expiratory flow (PEF). Primary outcome of this study was the rate of hospital admissions and secondary outcome were asthma score, FEV1, PEF and oxygen saturation. Results: Significant improvements were obtained in measured parameters in both Group 1 and Group 2. Values of measured parameters at hospital admission, 4th hour of treatment and while patients were in comfort were as follow: PEF values (Group 1: 173, 223, 220 L/min, p 0.001): Group 2 113, 141 , 192 L/min, p 0.001); FEV 1 (Group 1: 74.9%, 89.5%, 85.6%, p 0.0001; Group 2: 96, 89.8, 93.2 %, p 0.0001); O2 saturation (Group 1:93.2%, 95.6%, 96.8%, p 0.0001, Group 2: 93%, 95.2%, 96.6%, p 0.001); and asthma score (Group 1: 9.4, 6.6, 5.7, p 0.001, Group 2: 9.3, 6.8, 6.5, p 0.001). In all measured parameters significant improvements were observed with treatment modalities within both groups. No significant differences were found in all parameters between Group 1 and Group 2 (p 0.05). Conclusion: No significant differences were found in asthma score, FEV 1 and PEF parameters between systemic high-dose methylprednisolone and inhaled fluticasone treatment modalities in acute asthmatic attacks of children.
From Page
86
NaturalLanguageKeyword
Asthma , asthma exacerbation , inhaled fluticasone , systemic corticosteroid
JournalTitle
Dicle Medical Journal
To Page
94
JournalTitle
Dicle Medical Journal
Link To Document