Author/Authors :
Ece, Aydın Dicle Üniversitesi - Tıp Fakültesi - Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Türkiye , Yavuz, Sevgi Dicle Üniversitesi - Tıp Fakültesi - Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Türkiye , Tan, İlhan Dicle Üniversitesi - Tıp Fakültesi - Çocuk Hastalıkları Anabilim Dalı, Türkiye , Uluca, Ünal Dicle Üniversitesi - Tıp Fakültesi - Çocuk Hastalıkları Anabilim Dalı, Türkiye , Karabel, Duran Dicle Üniversitesi - Tıp Fakültesi - Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Türkiye
Title Of Article :
Two pediatric Henoch-Schönlein purpura cases whose severe gastrointestinal hemorrhage treated by cyclophosphamide
Abstract :
Henoch-Schönlein purpura (HSP) is a vasculitis, that involves various organ systems and show different clinical picture. It can be presented with purpura-like skin rash, abdominal pain, arthritis and renal involvement. Rarely, severe skin, gastrointestinal (GIS) and renal involvement occur and can lead to early or late complications. In this paper, it was aimed to report, two HSP children with severe GIS involvement as recurrent intestinal hemorrhage, which did not respond to high dose intravenous steroids, but successfully treated by intravenous cyclophosphamide. One of our patients had also severe necrotic skin lesions that necessitate skin grafting and the other had severe renal involvement as nephrotic syndrome. Intravenous cyclophosphamide may be useful in children with HSP, when severe GIS involvement not respond to high dose steroids.
NaturalLanguageKeyword :
Henoch , Schönlein purpura , severe system involvement , cyclophosphamide , management
JournalTitle :
Dicle Medical Journal
