Author/Authors :
Kılınç, Faruk Dicle Üniversitesi - Tıp Fakültesi - Endokrinoloji Bilim Dalı, Türkiye , Tuzcu, Alpaslan Kemal Dicle Üniversitesi - Tıp Fakültesi - Endokrinoloji Bilim Dalı, Türkiye , Beyaz, Coşkun Dicle Üniversitesi - Tıp Fakültesi - Endokrinoloji Bilim Dalı, Türkiye , Tuzcu, Şadiye Altun Özel Memorial Diyarbakır Hastanesi - Nükleer Tıp Kliniği, Türkiye
Abstract :
Werner’s syndrome (WS) is an extremely rare and autosomal recessive premature aging syndrome characterized by scleroderma-like skin changes, alopecia, leg ulcers, short stature, cataract, early atherosclerosis, osteoporosis, hypogonadism and increased susceptibility to malignancies and diabetes mellitus. It can be typically recognized at the third or fourth decades of life. Patients with WS usually die at the age of 40-50 years due to malignant tumors or atherosclerotic complications. Therefore, early recognition of WS is of great importance for genetic counseling and for the identification of malignant tumors, atherosclerosis, diabetes, or osteoporosis at an early stage, since they are the most important factors causing morbidity and mortality. In this article, growth retardation, premature aging, early cataract, the findings of hypergonadotropic hypogonadism syndrome was hospitalized and diagnosed with wermer 19-year-old male patient is presented.
