Çakırca, Gökhan Ceylanpınar State Hospital - Department of Biochemistry, Turkey , Polat, Cemal Dicle Üniversitesi - Tıp Fakültesi - Tıbbi Biyokimya AD, Türkiye , İnal, Ali Dicle University - Medical Faculty - Department of Medical Oncology, Turkey , Küçüköner, Mehmet Dicle Üniversitesi - Tıp Fakültesi - Onkoloji Bilim Dalı, Turkey , Mete, Nuriye Dicle University - Faculty of Medicine - Department of Biochemistry, Turkey , Işık, Fatma Birgül Dicle Üniversitesi - Tıp Fakültesi - Tıbbi Biyokimya AD, Türkiye

Comparison of CYFRA 21-1, CEA, CA 19-9 and CA 72-4 levels in gastric cancer

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Objective: Gastric cancer is the fourth most common malignancy, and the second most common cause of cancer mortality worldwide. The aim of this study was to investigate the role of biomarkers CYFRA 21-1, CA 19-9, CEA, CA72.4 at diagnosis and throughout the follow-up in patients with gastric cancer. Methods: 30 patients with gastric cancer diagnosed and 31 healthy people as a control group were included in this study. According to the TNM staging system, there were 16 patients with stage II and 14 patients with stage III in the group of patients with gastric cancer. CEA, CA 19-9, CA 72-4 and CYFRA 21-1 levels were studied by elektrochemiluminescence immunasay (ECLIA) method in the Cobas e 601 instrument. Results: Statistically the level of CA 72-4, CA 19-9, CEA and CYFRA 21-1 gastric cancer groups was found significant high accaording to healthy control group (p 0.01). Statistically compared with II stage patient group, the level of CA 19-9, CEA and CYFRA 21-1 of III stage patient group was found significant high (p 0.01). The diagnostic cut-off, sensitivity and specificity for CEA were 4.15 ng/ mL, 46 % and 96%, respectively; for CA 19-9 were 24.50 U/mL, 17 % and 96 %; for CA 72-4 were 2.46 U/mL, 53 % and 96% and for CYFRA 21-1 were 3.36 ng/mL, 46% and 100%. Conclusion: Our study demonstrates that the association of biomarkers CYFRA 21-1, CEA, and CA72.4 provides a valuable contribution in the follow-up of gastric cancer patients.

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Gastric cancer , tumor markers , CYFRA 21 , 1

Dicle Medical Journal

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