Gözükara, İlay Erzurum Nenehatun Kadın Hastalıkları ve Doğum Hastanesi, Türkiye , Uludağ, Eda Ülkü Erzurum Nenehatun Kadın Hastalıkları ve Doğum Hastanesi, Türkiye , Kucur, Suna Kabil Dumlupınar University - Evliya Celebi Hospital - Obstetrics and Gynecology Department, Turkey , Yılmaz, Havva Erzurum Bölge Eğitim ve Araştırma Hastanesi - Dahiliye Bölümü, Türkiye , Çarlıoğlu, Ayşe Erzurum Bölge Eğitim ve Araştırma Hastanesi - Dahiliye Bölümü, Türkiye

Evaluation of lipid parameters and family history of diabetes mellitus in polycystic ovary syndrome

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Objective: In the present study we investigated lipid parameters of Polycystic Ovary Syndrome (PCOS) patients and Diabetes Mellitus (DM) history of their family and relatives. Methods: In this cross-sectional study, one hundred and twenty patients with PCOS and 30 healthy controls were involved at Erzurum Research and Training Hospital. History, Body mass index (BMI), ultrasonography findings, blood hormone profiles (Follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), thyroid-stimulating hormone (TSH), total and free testosterone (Total-T and Free-T), prolactin (PRL)), and serum lipids (total cholesterol (Total-C), high-density cholesterol (HDL-C), low-density cholesterol (LDL-C), and triglycerides (TG), fasting blood glucose and plasma insulin level were measured. HOMA-IR (Homeostatic model assessment-insulin resistance) was calculated. Results: DM history in the family was found in 29 (24%) of PCOS patients and 2 (6%) of healthy controls. The difference between groups was statistically significant (p 0.05). DM history in the relatives was determined in 45 (35%) PCOS patients and 5 (17%) controls. The difference between groups was statistically significant (p 0.05). HOMA-IR, fasting glucose and insulin levels were significantly higher in PCOS patients (p 0.05). Lipid parameters were not significantly different between the two groups. Conclusion: Frequency of DM in the family and relatives of PCOS patients was significantly more common than controls. In contrast to previous studies, no deterioration was found in lipid parameters in patient with PCOS.

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PCOS , Family history , DM , lipid parameters

Dicle Medical Journal

417