Uludağ, Eda Ülkü Erzurum Nenehatun Kadın Hastalıkları ve Doğum Hastanesi, Türkiye , Gözükara, İlay Erzurum Nenehatun Kadın Hastalıkları ve Doğum Hastanesi, Türkiye , Kucur, Suna Kabil Erzurum Nenehatun Kadın Hastalıkları ve Doğum Hastanesi, Türkiye , Keskin, Havva Erzurum Bölge Eğitim ve Araştırma Hastanesi - Dahiliye Kliniği, Türkiye , Kılıç, Halime Erzurum Nenehatun Kadın Hastalıkları ve Doğum Hastanesi, Türkiye , Kamalak, Zeynep Erzurum Nenehatun Kadın Hastalıkları ve Doğum Hastanesi, Türkiye , Kargılı, Ayşe Erzurum Bölge Eğitim ve Araştırma Hastanesi - Endokrinoloji Kliniği, Türkiye , Durmaz, Şenay Arıkan Erzurum Bölge Eğitim ve Araştırma Hastanesi - Endokrinoloji Kliniği, Türkiye

C-reactive protein level and obesity as cardiovascular risk factors in polycystic ovary syndrome

26875

Objective: To investigate the role of C-reactive protein (CRP) level elevation and obesity for the increased cardiovascular disease risk in polycystic ovary syndrome (PCOS). Methods: A hundred and nine patients with PCOS and 30 age matched healthy volunteers with regular menstrual cycle are involved in the study. PCOS group is further subdivided into three subgroups according to the body mass index (BMI). Subgroups included 54 with BMI 25, 22 with BMI 25-30, and 33 with BMI 30. Blood samples for glucose, insulin, uric acid, and CRP were collected in the morning after overnight fasting (12 hours). Homeostasis model assessment-insulin resistance (HOMA-IR) was calculated. Results: Fasting blood glucose, insulin, and HOMA-IR was significantly higher in PCOS group (p=0.02, p=0.01 and p=0.02). CRP level was higher in subgroup with BMI 30. High CRP level in PCOS was found to be independent from BMI (p 0.001). HOMA-IR and insulin level was higher in the subgroup with BMI 30. When compared with the control group high insulin level was the only to be statistically significant in obese PCOS patients (p=0.005). HOMA-IR was higher in PCOS subgroup with BMI 30 when compared with controls and the PCOS subgroup with BMI 25 (p 0.001, p= 0.003). Conclusion: Obesity, hyperinsulinemia, and high CRP levels are seemed to be related and potentiating each other in PCOS. Struggling with obesity is one of the most important issues for preventive medicine.

426

PCOS , CRP , obesity , cardiovascular risk

Dicle Medical Journal

431