Author/Authors :
Rifaioglu, Emine Nur Mustafa Kemal University - Tayfur Ata Sökmen Medical School - Department of Dermatology, Turkey , Erfan, Gamze Namık Kemal University - School of Medicine - Dermatology Department, Turkey , Kaçar, Seval Doğruk Kocatepe University - School of Medicine - Dermatology Department, Turkey , Güzel, Savaş Namık Kemal University - School of Medicine - Biochemistry Department, Turkey , Alpsoy, Şeref Namık Kemal University - Faculty of Medicine - Department of Cardiology, Turkey , Kulaç, Mustafa Namık Kemal University - School of Medicine - Dermatology Department, Turkey , Karaca, Şemsettin Katip Çelebi University - School of Medicine - Dermatology Department, Turkey , Şen, Bilge Bülbül Mustafa Kemal University - Tayfur Ata Sökmen Medical School - Department of Dermatology, Turkey , Ekiz, Özlem Mustafa Kemal University - Tayfur Ata Sökmen Medical School - Department of Dermatology, Turkey , Şen, Nihat Mustafa Kemal University - School of Medicine - Cardiology Department, Turkey
Title Of Article :
Lectin-like oxidized low density lipoprotein receptor 1(LOX-1) levels and endothelial dysfunction in patients with primary essential hyperhidrosis
شماره ركورد :
26908
Abstract :
Objective: Primary essential hyperhidrosis (PEH) is a disorder characterized by excessive sweating of palms, soles and axilla. Although its etiology was not fully understand, increased activity of the autonomic nervous system may play a role in the pathogenesis of PEH. In the study we aimed to investigate flow mediated dilatation and lectin like oxide LDL receptor 1 (LOX-1) levels as an indicator of endothelial dysfunction in patient with PEH. Methods: Thirty-three PEH patients diagnosed with starch-iodine test and age- and sex-matched 19 healthy controls were included in the study. Flow-mediated dilatation was performed by ultrasonographical measurement of brachial artery. Serum LOX-1 levels were analyzed with Enzyme-Linked Immuno-Sorbent Assay (ELISA) kit. Results: Brachial artery FMD diameters and post-nitrate dilatation diameters were not different between patients and the controls. There was no difference between patient and control groups when compared for LOX-1 levels. Conclusion: Larger studies are needed to understand, indeed, whether excessive hyperhidrosis in PEH is only a peripheral excessive response to normal sympathetic activity or a systemic sympathetic hyperactivity with cardiovascular effects, which is disguised by compensatory mechanisms, such as nitric oxide (NO).
From Page :
529
NaturalLanguageKeyword :
endothelial dysfunction , flow mediated dilatation , lectin like oxidized low density lipoprotein receptor 1 , primary essential hyperhidrosis
JournalTitle :
Dicle Medical Journal
To Page :
532
Link To Document :
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