Turan, Mehmet İbrahim Diyarbakır Research and Educational Hospital - Department of Pediatric Neurology, Turkey , Çayır, Atilla Erzurum Research and Educational Hospital - Department of Pediatric Endocrinology, Turkey , Esin, İbrahim Selçuk Atatürk University - Faculty of Medicine - Department of Child Psychiatry, Turkey , Demir, Fikri Diyarbakır Research and Educational Hospital - Department of Pediatric Cardiology, Turkey , Tan, Hüseyin Atatürk University - Faculty of Medicine - Department of Pediatric Neurology, Turkey

The effects of carbamazepine on thyroid functions in childhood epilepsy

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Objective: To investigate the effects of carbamazepine therapy on thyroid function tests in children Methods: The carbamazepine group consisted of 58 children under observation for epilepsy, and the control group of 54 healthy children. Age of onset, length of drug use, drug dosage and laboratory parameters including free triiodothyronine (FT3), free thyroxin (FT4) and thyrotropin (TSH) were recorded. These data were then compared against those from the control group. Results: In the carbamazepine group, FT3 was 3.86 ± 0.43 pg/mL, FT4 was 1.15 ± 0.18 mg/dL and TSH: 2.58 ± 1.33 ml U/L. In the control group, FT3 was 4.13 ± 0.59 pg/ mL, FT4 1.34 ± 0.13 mg/dL and TSH was 2.06 ± 0.89 ml U/L. No statistically significant difference between rates of subclinical hypothyroidism was determined between the two groups (p=0.196). Conclusion: Although, carbamazepine reduces thyroid hormone concentrations, rarely causes hypothyroidism.

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Child , carbamazepine , thyroid function tests

Dicle Medical Journal

536