Author/Authors :
Türkoğlu, Ahmet Dicle Üniversitesi - Tıp Fakültesi, Genel Cerrahi Kliniği, Türkiye , Çetinkaya, Ziya Fırat Üniversitesi - Tıp Fakültesi - Genel Cerrahi Anabilim Dalı, Türkiye , Girgin, Mustafa Fırat Üniversitesi - Tıp Fakültesi - Genel Cerrahi Anabilim Dalı, Türkiye , Ayten, Refik Fırat Üniversitesi - Tıp Fakültesi - Genel Cerrahi Anabilim Dalı, TÜRKİYE , Kanat, Burhan Hakan Elazığ Eğitim ve Araştırma Hastanesi - Genel Cerrahi Kliniği, Türkiye , Binnetoğlu, Kenan Fırat Üniversitesi - Tıp Fakültesi - Genel Cerrahi Anabilim Dalı, Türkiye , Aksu, Ali Harput Devlet Hastanesi - Genel Cerrahi Kliniği, TÜRKİYE
Abstract :
Objective: The aim of this study is to investigate retrospectively the impact of the various prognostic factors on survival in patients with colorectal cancer. Methods: The clinical records, pathology and operation reports of 126 patients in 154 patients operated for colorectal cancer General Surgery Clinic of Fırat University Hospital between 1994 and 2005 years. The effects of the prognostic factors on 2-years, 5-years and 10-years survival, overall survival (OS) and disease-free survival (DFS) were evaluated. The survival durations are presented as months. Results: The mean age was 57.5 ± 15.2. The median duration of follow-up was 44,5 month. The median OS was 60 months. The median DFS in stage I-III patients was 62 months. According to the univariate analysis, the factors found significant in both OS and DFS rates were the following; stage of the cancer, extent of bowel wall penetration, lymph nodes metastasis, distant metastasis, pathologic stage, surgical margin, pretreatment CEA levels and type of surgery. The age and histologic type of tumor were related to only OS. The following variables were independent prognostic factors for both OS and DFS as determined by multivariate analysis; stage of the cancer, extent of bowel wall penetration and distant metastasis. Conclusion: A large number of prognostic factors are available to help predict the outcome of patients with colorectal cancer after surgery. In order to predict survival more accurately, a scoring system can be created that involving not only prognostic factors determined by multivariate analysis, but also prognostic factors determined by univariate analysis.
