Author/Authors :
Karanfil, Ramazan Sutcu Imam University - Medical Faculty - Department of Forensic Medicine, Turkey , Keten, Alper Council of Forensic Medicine, Kahramanmaraş Branch, Turkey , Zeren, Cem Mustafa Kemal Üniversitesi - Tıp Fakültesi - Adli Tıp Ana Bilim Dalı, Türkiye , Rifaioğlu, Emine Nur Mustafa Kemal Üniversitesi - Tıp Fakültesi - Dermatoloji Anabilim Dalı, Türkiye , Göktaş, M. Tuğrul Atatürk Education and Research Hospital - Department of Pharmacology, Turkey
Abstract :
Objective: Alcohol abuse remains to be an important problem in the world. In forensic medicine practice, alcohol and its metabolites should be detected in the body in order to determine whether a person has taken alcohol or not. Therefore, detection of ethyl glucuronide in such keratinous tissues as nails and hair following alcohol intake is important. In the present study, we compared hair ethyl glucuronide concentrations with nail ethyl glucuronide (EtG) concentrations. Methods: Hair and nail specimens were obtained from a total of 16 people taking alcohol. The specimens were analyzed with LC/MS/MS technique. Ethyl glucuronide concentrations of hair specimens were compared with those of nail specimens. Results: Ethyl glucuronide concentrations were 1.33-65.67 (+/- SD16.57) ppb in hair specimens and 4.27-225.03 (+/- SD 59.77) ppb in nail specimens. Hair ethyl glucuronide concentrations were correlated with nail ethyl glucuronide concentrations (r=0,808, p 0.001). Conclusion: This study showed that ethyl glucuronide concentrations in hair and nails could be determined. This suggests that detection of nail ethyl glucuronide concentrations can be useful in people without hair. In addition, there was a significant relationship between hair and nail ethyl glucuronide concentrations.
NaturalLanguageKeyword :
Alcohol , EtG , hair , nail
