Türkcü, Gül Dicle Üniversitesi - Tıp Fakültesi - Patoloji Anabilim Dalı, Turkey , Keleş, Ayşe Nur Dicle Üniversitesi - Tıp Fakültesi - Patoloji Anabilim Dalı, Turkey , Alabalık, Ulaş Dicle Üniversitesi - Tıp Fakültesi - Patoloji Anabilim Dalı, Turkey , Bozkurt, Yaşar Dicle Üniversitesi - Tıp Fakültesi - Üroloji Anabilim Dalı, Turkey , Büyükbayram, Hüseyin Dicle Üniversitesi - Tıp Fakültesi - Patoloji Anabilim Dalı, Turkey

A case of Choriocarcinoma primarily located in the urinary bladder

27252

Choriocarcinoma is a tumor with poor prognosis which usually develops in the uterus and ovaries in females and testes in males. Choriocarcinomas primarily located in the urinary bladder occur extremely rare.In the radiological examination of the 28 year old male patient presented with cough, difficulty in breathing, dysuria and hematuria; lung lesions compatible with metastasis and a mass which was extending inside of the lumen in the anterior wall of the urinary bladder were determined. During the cystoscopic investigation, an incomplete transurethral resection was applied to the tumor. In the histopathological evaluation of the tumor tissue, cells compatible with syncytiotrophoblasts were observed among the polyhedral large mononuclear cells. While positive staining with pancytokeratin, cytokeratin 7, high molecular weight cytokeratin, human plasental lactogen, and human corionic gonadotrophin was observed in the tumor tissue, there was not any staining with epithelial membrane antigen, carcinoembryonic antigen, CD30, p63, and cytokeratin 20. Present histopathological and immunohistochemical findings were evaluated as compatible with coriocarcinoma.Because of being seen rarely, having poor prognosis, causing death due to metastasis, the necessity of holding in mind in the differential diagnosis of high grade urothelial carcinomas, it is purposed to present the case accompanied by literature information.

528

Choriocarcinoma , Bladder , Syncytiotrophoblasts

Dicle Medical Journal

531