Author/Authors :
Gupta, Monika University of Health Sciences - Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences (PGIMS) - Department of Pathology, India , Malik, Shivani University of Health Sciences - Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences (PGIMS) - Department of Pathology, India , Kalra, Rajnish University of Health Sciences - Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences (PGIMS) - Department of Pathology, India , Sharma, Nisha University of Health Sciences - Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences (PGIMS) - Department of Pathology, India , Singh, Sunita University of Health Sciences - Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences (PGIMS) - Department of Pathology, India , Gupta, Veena University of Health Sciences - Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences (PGIMS) - Department of Pathology, India , Jain, Promil University of Health Sciences - Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences (PGIMS) - Department of Pathology, India , Sen, Rajeev University of Health Sciences - Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences (PGIMS) - Department of Pathology, India
Abstract :
Objective: In recent years, during routine examination of bone marrow aspirates, an increased plasma cell percentage has been noted in a good number of cases which included both neoplastic and non-neoplastic diseases. An attempt has been made to observe the spectra of conditions with plasmacytosis in bone marrow. Methods: The present study was conducted in the department of pathology over a period of one year. A total of 114 bone marrow aspirates that showed increased plasma cells ( 3.5%) constitute the study material. A detailed relevant clinical examination followed by complete blood count, peripheral smear examination and bone marrow aspiration was done in all cases. Results: There was slight female predominance with male to female ratio of 1:1.1. The majority of patients were in 4th decade. The plasma cell concentration ranged from 5% to 36%. As far as the etiology is concerned, 96 cases (84.2%) were non-neoplastic and 18 cases (15.7%) had neoplastic etiology. Conclusion: Bone marrow plasmacytosis can present as diagnostic dilemma and some time can be challenging to differentiate reactive from neoplastic condition as there is an overlap both in counts and morphology. Each case with plasmacytosis especially in the overlap range requires complete clinical evaluation, individualized investigations and more specific tests like immunoelectrophoresis and bone marrow biopsy with immunohistochemistry to arrive at a final diagnosis for patient management.
NaturalLanguageKeyword :
Reactive plasmacytosis , bone marrow , multiple myeloma , megaloblastic anaemia
