Author/Authors :
Eren, Tunç İstanbul Medeniyet Üniversitesi - Göztepe Eğitim ve Araştırma Hastanesi - Genel Cerrahi AD, Turkey , Tombalak, Ercüment İstanbul Medeniyet Üniversitesi - Göztepe Eğitim ve Araştırma Hastanesi - Genel Cerrahi AD, Turkey , Burcu, Buşra İstanbul Medeniyet Üniversitesi - Göztepe Eğitim ve Araştırma Hastanesi - Genel Cerrahi AD, Turkey , Özemir, İbrahim Ali İstanbul Medeniyet Üniversitesi - Göztepe Eğitim ve Araştırma Hastanesi - Genel Cerrahi AD, Turkey , Leblebici, Metin İstanbul Medeniyet Üniversitesi - Göztepe Eğitim ve Araştırma Hastanesi - Genel Cerrahi AD, Turkey , Ziyade, Sedat Bezmialem Vakıf Üniversitesi - Göğüs Cerrahisi AD, Turkey , Ekinci, Özgür İstanbul Medeniyet Üniversitesi - Göztepe Eğitim ve Araştırma Hastanesi - Genel Cerrahi AD, Turkey , Alimoğlu, Orhan İstanbul Medeniyet Üniversitesi - Göztepe Eğitim ve Araştırma Hastanesi - Genel Cerrahi AD, Turkey
Title Of Article :
Predictive value of Neutrophil/Lymphocyte Ratio for the Diagnosis and Severity of Disease in Acute Appendicitis
Abstract :
Objective: Our aim was to investigate the value of neutrophil/lymphocyte ratio for the diagnosis of acute appendicitis, and for the prediction of gangrenous/perforated appendicitis.Methods: The medical records of 162 patients having undergone appendectomies between January 2013 and September 2014 including age, gender, preoperatively assessed C-reactive protein (CRP), white blood cell (WBC), neutrophil (NEU), lymphocyte, and neutrophil/lymphocyte ratio (NLR) values were retrospectively evaluated, compared with the postoperative histopathological findings, and statistically analyzed.Results: The study group consisted of 97 (59.9%) men, and 65 (40.1%) women with a median age of 36.01 (18-90). Histopathological examinations revealed normal appendix in 21 (12.96%), and acute appendicitis in 141 (87.04%) patients. Appendiceal gangrene/perforation rate was 25.31%. Lymphocyte counts were decreased, while CRP, WBC, NEU, and NLR values were increased in acute appendicitis (p 0.05). NLR ≥4.0 was associated with 16.9 times increased possibility of acute appendicitis [p 0.01, Odds ratio (OR):16.864, 95% Confidence interval (CI):4.696-60.568]. In cases with NLR≥4.5, it was detected that the risk of appendiceal gangrene/perforation was 3.2 times higher [p 0.01, OR:3.258, 95% CI: 1.468-7.228].Conclusions: In addition to physical examination and other diagnostic methods, NLR can be considered as a useful auxiliary tool for the diagnosis of acute appendicitis, and for the prediction of gangrenous/perforated appendicitis.
NaturalLanguageKeyword :
Neutophil , lymphocyte ratio , acute appendicitis , apendiceal gangrene , perforation
JournalTitle :
Dicle Medical Journal
