Author/Authors
cemil, bengü çevirgen s.b. dışkapı yıldırım beyazıt eğitim ve araştırma hastanesi - dermatoloji kliniği, Turkey , ataş, hatice s.b. dışkapı yıldırım beyazıt eğitim ve araştırma hastanesi - dermatoloji kliniği, Turkey
Title Of Article
The Effect of Biological Treatment onto Systemic Inflammatory Markers and Plateletcrit in Psoriasis Patients
شماره ركورد
27374
Abstract
Objectives: Psoriasis is a chronic inflammatory skin disease characterized by abnormal proliferation of keratinocytes and inflammatory cell infiltration. Circulating inflammatory markers are increased in patients with psoriasis. The objective of this study is to assess neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR), RDW to platelet ratio (RPR) and plateletcrit (PCT) as inflammatory markers in patients with psoriasis whom treated with biological agents. Methods: Forty-two patients with psoriasis vulgaris whom treated with biological agents were evaluated retrospectively. Information about demographics, clinics, and complete blood count of the patients before initiation and after 3 months of biological treatment were collected. Results: Erythrocyte sedimantation rate (ESR), C-reactive protein (CRP), neutrophil, platelet, PCT, RDW, NLR, and PLR were significantly reduced in the posttreatment results compared with the pretreatment results (p 0,05). Also, there were no statistically significant difference in terms of MPV, PDW, LMR, and RPR results (p 0,05). Conclusion: NLR, PLR and PCT may be used as a marker to evaluate biological agent treatment efficacy on psoriasis vulgaris patients.
From Page
477
NaturalLanguageKeyword
biological therapy , biomarkers , psoriasis
JournalTitle
Dicle Medical Journal
To Page
483
JournalTitle
Dicle Medical Journal
Link To Document