مرکز منطقه ای اطلاع رساني علوم و فناوري - IL-6 Promoter Polymorphism in Alopecia Areata

Abstract :

Objectives: Alopecia areata (AA) is a T-cell mediated autoimmune disease and cytokines play important roles development of this disease. Previous studies showed significantly increased serum IL–6, as a pro-inflammatory cytokine, levels in AA patients compared to healthy controls. The -174G/C polymorphism in the promoter of the IL–6 gene that affects IL–6 serum levels. The aim of present study was to assess whether IL–6 -174G/C promoter polymorphism is associated with AA. Methods: The study included 146 unrelated patients with AA and 133 unrelated healthy controls. The genotyping of IL–6 gene - 174 G/C polymorphism was performed by polymerase chain reaction (PCR) based restriction fragment length polymorphism (RFLP) analysis. Results: Genotype and allele distribution of IL–6 gene -174 G/C polymorphism was not found to be significantly different between patients and controls (p=0.749 and p=0.228, respectively). Conclusion: This study shows that IL–6 gene -174 G/C polymorphism is not a predisposing factor for AA.