Boussalah, Nouria Université de Tlemcen - Faculté desSciences - Département de Chimie, Laboratoire de Chimie Organique, Substances Naturelles et Analyses, Algeria , Touzani, Rachid Université Mohamed Premier - Faculté des Sciences, Faculté Pluridisciplinaire de Nador - Département de Chimie, Laboratoire de Chimie Appliquée et Environnement URAC-18, Morocco , Ghalem, Said Université de Tlemcen - Faculté des Sciences - Département de Chimie, Laboratoire de Chimie Organique, Substances Naturelles et Analyses, Algeria , El Bali, Brahim Université Mohamed 1er - Faculté des Sciences - Département de Chimie, LCSMA, Morocco , Dusek, Michal Institute of Physics, Czech , Fejfarova, Karla Institute of Physics, Czech , El Kadiri, Sghir Université Mohammed Ier - Faculté des Sciences - Département de Chimie, Laboratoire de Chimie Appliquée et Environnement (URAC 18), Morocco

SYNTHESIS AND CRYSTALE STRUCTURE OF [Bis-(3,5-dimethyl-pyrazol-1-ylmethyl)-amino]-acetic acid methyl ester

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One equivalent of diethylisopropyleamine was added to a suspension of one equivalent of glycine methylester hydrochloride in anhydrous DMF. The mixture was stirred under nitrogen for 5 minutes and a solution of two equivalents of (3,5-dimethyl-1H-pyrazol-1-yl)methanol in anhydrous DMF was added dropwise. The reaction was allowed to stir from four days under nitrogen atmosphere at room temperature. The mixture was dissolved in water and the compound was extracted by diethyl ether. The organic layers was washed with saturated brine solution, dried, filtered and concentrated to yield the oils which gives mono crystal. The structure was confirmed by X-ray crystal with monoclinic P21/c group, having good π-π interactions.

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Crystal structure , Pyrazole , Nitrogen compound , Glycine , Amino acid

Journal Marocain De Chimie Hétérocyclique

32