Author/Authors :
Harmaoui, A. Université Mohammed V Rabat-Agdal - Laboratoire de Chimie Organique Hétérocyclique URAC21, Maroc , Lazar, S. Université Hassan II - Faculté des Sciences et Techniques - Laboratoire de Biochimie, Maroc , Leger, J. M. Université Victor Segalen Bordeaux II - EA 2962, Pharmacochimie, France , Jarry, C. Université Victor Segalen Bordeaux II - EA 2962, Pharmacochimie, France , Kandri Rodi, Y. Université Sidi Mohamed Ben Abdallah - Faculté des Sciences et Techniques - Laboratoire de Chimie Organique Appliquée, Maroc , Essassi, E. M. Université Mohammed V Rabat-Agdal - Laboratoire de Chimie Organique Hétérocyclique URAC21, Maroc , Essassi, E. M. Moroccan Foundation for Advanced Science, Innovation and Research (MASCIR), Maroc , Guillaumet, G. Université d’Orléans - Institut de Chimie Organique Analytique, CNRS 6005 - UMR, France
Abstract :
This article is about the action of 2-aminobenzimidazole 1 on 4-arylidene-2-methyl(phenyl)oxozolin-5-one 2a-d in n-butanol. The reaction leads to pyrimido[1,2-a]benzimidazoles 3a-d expected with satisfying yield. We also showed that the obtained results are not dependable on the nature of the substituent in position 2. The derivative 3b has been alkylated within solid-liquid phase transfer catalysis conditions. The structures of obtained different components have been determinated via spectroscopic process and X-rays diffraction namely in case of compound 5. The obtained pyrimido[1-2a]benzimidazoles as their analogous are likely to be applicable in the pharmacological field.
NaturalLanguageKeyword :
oxazolines , 2 , aminobenzimidazole , pyrimido[1 , 2 , a]benzimidazole , phase transfer catalysis (PTC) , X –ray study
