Author/Authors :
Tribak, Z. Sidi Mohamed Ben Abdellah University - Faculty of Science and Technology of Fes - Laboratory of Applied Chemistry-, Laboratory of Applied Organic Chemistry, Morocco , Kandri Rodi, Y. Sidi Mohamed Ben Abdellah University - Faculty of Science and Technology of Fes - Laboratory of Applied Chemistry-, Laboratory of Applied Organic Chemistry, Morocco , Kharbach, Y. Sidi Mohamed Ben Abdellah University - Faculty of Science and Technology of Fes - Laboratory of Applied Chemistry-, Laboratory of Applied Organic Chemistry, Morocco , Haoudi, A. Sidi Mohamed Ben Abdellah University - Faculty of Science and Technology of Fes - Laboratory of Applied Chemistry-, Laboratory of Applied Organic Chemistry, Morocco , Skalli, M.K. Sidi Mohamed Ben Abdellah University - Faculty of Science and Technology of Fes - Laboratory of Applied Chemistry-, Laboratory of Applied Organic Chemistry, Morocco , Mazzah, A. Université Lille1 - USR 3290 Miniaturisation pour l’analyse, la synthèse et la protéomique, France , Akhazzane, M. Université Sidi Mohammed Ben Abdallah - Cité de l’innovation, Maroc , Essassi, E.M. Université Mohammed V - Faculty of Sciences - Laboratory of Organic Heterocyclic Chemistry, Morocco
Abstract :
Isatin derivatives are endogenous natural compounds under intense development in medicinal chemistry. A wide variety of these compounds have valuable pharmacological activities The novel 5-chloroisatin and 5-bromoistin derivatives were synthesized by the alkylation reaction on the nitrogen atom N, using a brominated alkylating agent in DMF under phase transfer catalysis conditions (PTC). The reaction leads to the expected products with good yields and structures of various compounds are determined by the analytical techniques NMR 1H, 13C and X-ray crystallographic study.
NaturalLanguageKeyword :
Alkylation studies , isatin , heterocyclic , X , ray , synthesis
