Author/Authors :
jeroundi, dounia sidi mohamed ben abdellah university - faculty of sciences and techniques - laboratory of applied organic chemistry, Fez, Morocco , chakroune, said sidi mohamed ben abdellah university - faculty of sciences and techniques - laboratory of applied organic chemistry, Fez, Morocco , kandri rodi, youssef sidi mohamed ben abdellah university, - faculty of sciences and techniques - laboratory of applied organic chemistry, Fez, Morocco , chraibi, marwa sidi mohamed ben abdellah university - faculty of sciences and techniques - laboratory of microbial biotechnology, Fez, Morocco , el hadrami, el mestafa sidi mohamed ben abdellah university - faculty of sciences and techniques - laboratory of applied organic chemistry, Fez, Morocco , ben-tama, abdeslem sidi mohamed ben abdellah university - faculty of sciences and techniques - laboratory of applied organic chemistry, Fez, Morocco , fikri benbrahim, kaoutar sidi mohamed ben abdellah university - faculty of sciences and techniques - laboratory of microbial biotechnology, Fez, Morocco , essassi, el mokhtar mohammed v-agdal university - competence center pharmacochemistry - laboratory of heterocyclic organic chemistry, Rabat, Morocco
Abstract :
A new heterocyclic systems containing pyrrolobenzodiazepine (PBD) have been synthesizedand investigated for their pharmacological property. In present study, we have prepared PBDsN-alkylated and we report results of their antibacterial activity against a range of Grampositive and Gram negative bacteria. The result of the Minimum inhibiting concentration(MIC) varied from one bacterium to another.
NaturalLanguageKeyword :
Pyrrolobenzodiazepine , Antibacterial activity , Bacteria , Antitumor activity , N , alkylation
