Author/Authors :
ellouz, mohamed mohammed v university in rabat - centre de recherche en sciences des médicaments, faculté des sciences - laboratoire de chimie organique hétérocyclique, Rabat, Morocco , sebbar, nada kheira mohammed v university in rabat - centre de recherche en sciences des médicaments, faculté des sciences - laboratoire de chimie organique hétérocyclique, Rabat, Morocco , abad, nadeem mohammed v university in rabat - centre de recherche en sciences des médicaments, faculté des sciences - laboratoire de chimie organique hétérocyclique, Rabat, Morocco , hlimi, fouzia mohammed v university in rabat - centre de recherche en sciences des médicaments, faculté des sciences - laboratoire de chimie organique hétérocyclique, Rabat, Morocco , abdelahi, mohamed mokhtar mohamed mohammed v university in rabat - centre de recherche en sciences des médicaments, faculté des sciences - laboratoire de chimie organique hétérocyclique, Rabat, Morocco , essassi, el mokhtar rabat design center - moroccan foundation for advanced science, innovation and research (mascir), Rabat, Morocco , essassi, el mokhtar mohammed v university in rabat - centre de recherche en sciences des médicaments, faculté des sciences - laboratoire de chimie organique hétérocyclique, Rabat, Morocco
Title Of Article :
SYNTHESIS OF NEW 1,2,3-TRIAZOLYLMETHYL-2H-1,4- BENZOTHIAZIN-3(4H)-ONE DERIVATIVES
Abstract :
Novel 1,4-benzothiazine derivatives containing 1,2,3- triazole moiety were synthesized by exploiting a Huisgen [3+2] cycloaddition. Starting from 2-(substituted)-3,4- dihydro-2H-1,4-benzothiazin-3-one, a number of 1,4-benzothiazin-3-one derivatives were synthesized using propargyl bromide to give a 2-(substituted)-4-(prop-2-ynyl)-3,4-dihydro-2H-1,4-benzothiazi-3-one in good yields. All structures of the synthesized compoundswere elucidated on the basis of spectral analyses (1H, 13C NMR and IR).
NaturalLanguageKeyword :
1,2,3 , Triazole , 1,4 , Benzothiazin , 3 , one , 1,3 , dipolar Cycloaddition , Spectroscopic methods
