hafidh, afifa université de tunis, institut préparatoire aux etudes d’ingénieurs de tunis ipeit - département de chimie, laboratoire matériaux et environnement, Tunisia , chaabane, hédia institut national de recherche et d’analyse physicochimique, pôle technologique de sidi-thabet - laboratoire de biotechnologie, Tunis, Tunisia , touati, fathi institut national de recherche et d analyse physico-chimique (inrap), technopole sidi thabet - laboratoire matériaux traitement et analyse, Tunis, Tunisia

SYNTHESIS AND BIOLOGICALEVALUATION OF NOVEL HETEROCYCLIC DERIVATIVES

28046

In the current work, novel heterocyclic derivatives containing 1,3,4-thiadiazole ring have been successfully synthesized through nucleophilic addition reaction, bythe condensation of 1,3,4-thiadiazole-2,5-diamines (1) as starting material with variouselectrophilic agents. The newly synthesized compounds were investigated for theirantimicrobial activities. Structures of all the prepared compounds have been proved using(FTIR), (1H-NMR) and (13C-NMR) spectra. The synthesized compounds were screened forantibacterial and antifungal activities against Escherichia coli gram(-), Salmonellatyphimurium gram(-), Staphylococus aureus gram(+), Enterococcus feaciumgram(+),Streptocoque B(agalactiae)gram (+) and Candida albicans. The synthesized compoundswere found to exhibit moderate to high antibacterial and antifungal efficiency against severaltested bacterial strains, using agar diffusion method and filter paper disc-diffusion method.Ampicillin was used as positive control for all strains except Candida albicans for whichNystatin was used. The prepared compounds manifested promising biological activity.

66

Antimicrobial activity , 1 , 3 , 4 , Thiadiazole , Sorbic acid , Phenacetine , Benzophenone

Journal Marocain De Chimie Hétérocyclique

81