köksal, mehmet erciyes üniversitesi - tıp fakültesi - tıbbi biyoloji ad, Turkey , doğan, serap erciyes üniversitesi - tıp fakültesi - radyoloji ad, Turkey , öztürk, figen erciyes üniversitesi - tıp fakültesi - patoloji ad, Turkey , cücer, nurhan erciyes üniversitesi - tıp fakültesi - tıbbi biyoloji ad, Turkey

Investigation of the Relationship Between the Largest Tumor Size, AgNOR area and AgNOR Count on Breast Cancer Cells

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Tumor size is an important parameter used to determine the prognosis and stage of breast cancer. We investigated a probable correlation between AgNOR area and tumor size to examine wheter the AgNOR parameters can also be tools of detecting the stage and predicting of the prognosis. The diameter of tumor size were obtained as a retrospectively from archive records. AgNOR number and AgNOR area were dedected using the slides, which obtained from archive. Patients were divided into groups according to the TNM classification system by tumor size. Thus, patients with a tumor diameter between 5-10 mm are included in T1b (n = 8 ), between 10-20 mm are included in T1c (n = 5), and between 20-50 mm are included in T2 ( n = 5) groups. Both mean AgNOR area and mean AgNOR count values had strong correlation with tumor diameters of patients ( Respectively r = 0.740 , P 0.000 , r = 0.771 ; P 0.000). When the statistical evaluations were done using the Tumor Nod Metastasis class of the tumor instead of tumor diameter, correlation appeared milder (r=0,709;P 0,001, r=0,646;P 0,004 with same respect). Three groups of tumor diameter had significantly different mean AgNOR area and mean AgNOR count values (Respectively; P=0,013;P=0,029). Presence of positive correlations between tumor diameter and AgNOR parameters indicates that AgNOR parameters have potantial to be usefull tools for staging of breast cancer and predicting the prognosis of the condition.

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Erciyes University Journal Of The Institute Of Science an‎d Technology

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