oyeyemi, o. babcock university - department of basic sciences, department of microbiology, Ilishan Remo, Nigeria , ezekiel, c. babcock university - department of microbiology, Ilishan Remo, Nigeria , ayeni, k. babcock university - department of microbiology, Ilishan Remo, Nigeria , nabofa, w. babcock university - department of physiology, Ilishan Remo, Nigeria , oyeyemi, i. university of medical sciences - department of biological sciences, Ondo, Nigeria , oyedele, o. babcock university - department of microbiology, Ilishan Remo, Nigeria , adefalujo, a. babcock university teaching hospital - department of radio-diagnostic, Ilishan Remo, nigeria , nwozichi, c. babcock university - school of nursing - department of adult health nursing, Ilishan Remo, Nigeria , dada, a. babcock university teaching hospital - department of chemical pathology, Ilishan Remo, Nigeria

A pilot biomonitoring study of bladder tumor antigen (BTA) in aflatoxin exposed Nigerian villagers

28645

Objective: To correlate the levels of bladder tumour antigen (BTA) with aflatoxin M1 (AFM) in a human population in Nigeria. Subjects and methods: A pilot, observational study was conducted with 22 human subjects randomly recruited from a Nigerian rural community. Serum and first morning urine of participants were analysed for human BTA and AFM1, respectively, using quantitative ELISA assays. Results: All the subjects were positive to AFM1 (mean = 0.235 ± 0.072 ng/mL) while 19 were positive to BTA (mean = 2.340 ± 1.741 ng/mL). A negative relationship occurred between human BTA and AFM level (r = −0.239; P = 0.285). Human BTA (2.86 ± 2.43 ng/mL; P = 0.306) and AFM1 (0.258 ± 0.065 ng/mL; P = 0.643) were higher in subjects 1–20 years. The two biomarkers were not also associated with sexes of the participants (P 0.05), although they were higher in the female subjects.

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Bladder tumor antigen , Aflatoxin M1 , Association , Bladder cancer pathophysiology , Nigeria

African Journal of Urology

156