Author/Authors :
prasetya, h. lambung mangkurat university - ulin general hospital, medical faculty - department of urology, Banjarmasin, Indonesia , purnomo, b.b. university of brawijaya - saiful anwar hospital, faculty of medicine - department of urology, Malang, Indonesia , mintaroem, k. university of brawijaya - faculty of medicine, - department of pathology, Malang, Indonesia , prawiro, s.r. university of brawijaya - faculty of medicine - department of microbiology, Malang, Indonesia
Title Of Article :
Sensitivity and specificity of 47 kDa polyclonal antibody for detection of bladder cancer cells in urine of hematuria patients
شماره ركورد :
28675
Abstract :
Objective: To investigate the performance analysis of immunocytochemistry using 47 kDa polyclonal antibody compared with cytology in urine of patients hematuria symptom. Patients and methods: Patients with a suspicion of bladder tumor based on workup of hematuria were prospectively collected. The voided urine was performed for cytology and test with 47 kDa polyclonal antibody. Results: This study involved 39 patients consisting of 35 (89.74%) male and 4 (10.25%) female patients. For male patients, they showed 6 (17.14%) of positive cytology cases and 25 (71.42%) of positive immunocytochemistry cases. For female patients, they showed 0 (0.00%) of positive cytology cases and 2 (50.00%) of positive immunocytochemistry cases. The sensitivity and specificity value for immunocytochemistry using polyclonal antibody to the 47 kDa were 100.00% (95% CI = 54.07%–100.00%) and 36.36% (95% CI = 20.40%–54.88%), respectively. The positive and negative predictive value for immunocytochemistry of polyclonal antibody to the 47 kDa were 22.22% (95% CI = 8.62%–42.26%) and 100.00% (95% CI = 73.54%–100.00%), respectively. In conclusion, urine detection with 47 kDa polyclonal antibodies has higher sensitivity value and negative predictive value (100.00%) than urine cytology. Conclusion: This technique becomes an alternative early detection of bladder cancer for high-risk populations which can be easily and specifically carried out in primary care in Indonesia.
From Page :
264
NaturalLanguageKeyword :
Bladder , Polyclonal antibody , Hematuria , Proteomic , Diagnostic performance
JournalTitle :
African Journal of Urology
To Page :
269
Link To Document :
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