Kılıçkap, Saadettin Hacettepe University - Institute of Oncology - Department of Medical Oncology, Turkey , Tapan, Ümit Hacettepe University - Faculty of Medicine - Department of Internal Medicine, Turkey , Yalçın, Şuayib Hacettepe University - Institute of Oncology - Department of Medical Oncology, Turkey

Metastasis to bone from gastric cancer: a single centre experience

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Aim. Bone metastasis is relatively uncommon with gastric carcinoma. Its complications have a negative impact on the quality of life and function of cancer patients. We planned a retrospective study to investigate the incidence and clinicopathological features of bone metastasis form gastric cancer and to explore the therapeutic outcome. Method. We retrospectively reviewed the clinical records of consecutive 253 patients with gastric cancer who admitted Outpatient Clinic of Medical Oncology in Hacettepe University. Result. Of 253 patients with gastric cancer, 26 patients (10.2%) were found to have skeletal metastases. The median age was 56 years. The vertebrae were the most frequent metastatic site (85%). Bone metastasis-related events (BMEs) included fracture, cord compression, severe bone pain, and radiation therapy because of the risk of fracture were found in 15 (58%) patients. Surgical treatment was given to 3 patients because of bone fracture and cord compression. The median survival was 130 days and 1-year survival was 27%. The median duration between diagnosis of skeletal metastasis and death was 68 days. Elevated alkaline phosphatase (ALP) level was associated with short survival. Conclusion. Skeletal metastasis-associated complications may significantly reduce the quality of life. Bone metastasis is a major health problem because of its complications including pain, pathologic bone fractures, and spinal cord compression.

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Gastric cancer , bone metastasis , incidence , survival , complication.

Cumhuriyet Medical Journal

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