Çetin, Meral Cumhuriyet Üniversitesi - Tıp Fakültesi - Kadın Hastalıkları ve Doğum Anabilim Dalı, Turkey , Yıldız, Çağlar Cumhuriyet Üniversitesi - Tıp Fakültesi - Kadın Hastalıkları ve Doğum Anabilim Dalı, Turkey , Çil, Fırat Cumhuriyet Üniversitesi - Tıp Fakültesi - Kadın Hastalıkları ve Doğum Anabilim Dalı, Turkey

Comparing the effectiveness of different misoprostol regimens on abortion time and the dosage of the drug

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Aim. To compare the effectiveness of 400 μg and 200 μg misoprostol administered by vaginal and oral route, repeated every six hours and four hours, respectively for second trimester pregnancy termination. Methods. In this study, which is a retrospective file review, we evaluated the efficacy of misoprostol treatment protocols used in our clinic. Medical files of a total of sixty women, aged 18-43 years, who was planned to have terminated second trimester pregnancy, were evaluated. Thirty three patients (group 1) received 200 μg oral and 200 μg vaginal misoprostol, repeated every 6 hours. Twenty seven patients (group 2) received 100 μg oral and 100 μg vaginal misoprostol, repeated every 4 hours. Exclusion criteria were systemic disease, a history of cervical operations, bleeding or spotting during the current pregnancy. If abortion did not occur within forty eight hours, the treatment was considered to be failed. Results. The mean induction–abortion interval of the group 2 was found to be significantly shorter than of the group 1 (16.6±8 h versus 10.3 ±7.9 h). The mean total dose of misoprostol of group 2 was significantly lower than of the group 1 (group 1, 1200±529μg; group 2, 622±390 μg). There were no side effects in the groups. Conclusion. It was found that lower dose of misoprostol repeated in short intervals was more effective than of the higher doses repeated in long intervals.

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Fetus , misoprostol , second trimester , pregnancy termination

Cumhuriyet Medical Journal

328