Author/Authors :
Amasyalı, Elvan Malazgirt Devlet Hastanesi - İç Hastalıkları Kliniği, Turkey , Kılıçlı, Fatih Cumhuriyet Üniversitesi - Tıp Fakültesi - Endokrinoloji ve Metabolizma Bilim Dalı, Turkey , Acıbucu, Fettah Cumhuriyet Üniversitesi - Tıp Fakültesi - Endokrinoloji ve Metabolizma Bilim Dalı, Turkey , Korkmaz, Serdal Cumhuriyet Üniversitesi - Tıp Fakültesi - Hematoloji Bilim Dalı, Turkey , Yönem, Özlem Cumhuriyet Üniversitesi - Tıp Fakültesi - Gastroenteroloji Bilim Dalı, Turkey , Uygungelen, Bülent Andırın Devlet Hastanesi - İç Hastalıkları Kliniği, Turkey , Say, Ramazan İskenderun Devlet Hastanesi - İç Hastalıkları Kliniği, Turkey , Arslan, Mübeccel Cumhuriyet Üniversitesi - Tıp Fakültesi - Radyoloji Anabilim Dalı, Turkey
Abstract :
Aim. The purpose of this study is to investigate the frequency of non-alcoholic fatty liver disease (NAFLD) in patients diagnosed as metabolic syndrome (MS) and also to find out its relation with serum uric acid levels. Methods. A total of 60 MS patients (26 male, 34 female) and 42 healthy individuals (21 male, 21 female) were included in the study. After a fasting period of 12 hours, serum glucose, triglyceride, high density lipoprotein, low density lipoprotein, uric acid and insulin levels were determined. HOMA-IR formula was used to determine insulin resistance. Ultrasonography was used in showing the grade of hepatosteatosis. Results. Mean serum uric acid level of the MS group was significantly higher than the control group in our study (p 0.05) and we observed that serum uric acid levels increase as the number of MS components increase. We found the frequency of hepatosteatosis in our metabolic syndrome patients to be 78.3%. Serum uric acid levels were significantly elevated in these patients and this elevation showed a positive correlation with the grade of hepatosteatosis. Conclusion. There is a close relationship between MS and serum uric acid levels and also with NAFLD. Especially the increase in serum uric acid levels were found to be directly related with the degree of hepatosteatosis. Relying on this fact; we think that the increased uric acid levels in MS patients could have played a role in the NAFLD pathogenesis.
