Terzi, Yunus Kasım Gülhane Askeri Tıp Akademisi - Tıbbi Biyoloji Anabilim Dalı, Turkey , Beyan, Cengiz Gülhane Askeri Tıp Akademisi - Hematoloji Bilim Dalı, Turkey , Kozan, Salih Gülhane Askeri Tıp Akademisi - Tıbbi Genetik Bilim Dalı, Turkey , Torun, Deniz Gülhane Askeri Tıp Akademisi - Tıbbi Genetik Anabilim Dalı, Turkey , Durmaz, Burak Gülhane Askeri Tıp Akademisi - Tıbbi Genetik Anabilim Dalı, Turkey , Kömürcü, Şeref Gülhane Askeri Tıp Akademisi - Tıbbi Onkoloji Bilim Dalı, Turkey , Bahçe, Muhterem Gülhane Askeri Tıp Akademisi - Tıbbi Genetik Bilim Dalı, Turkey , Güran, Şefik Gülhane Askeri Tıp Akademisi - Tıbbi Biyoloji Anabilim Dalı, Turkey

Acute myeloid leukemia case defined with complex karyotypic abnormalities long time after prostate cancer

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Acute myeloid leukemia (AML) is a type of leukemia which is characterized by the excessive accumulation of immature myeloid bone marrow precursor cells in the marrow itself, in peripheral blood and sometimes also in other tissues. During differentiation of leukemia cells, clonal chromosomal abnormalities emerge in bone marrow and in peripheral blood cells. These anomalies are important for the disease diagnosis and prognosis. Here, an AML case who underwent surgery for prostate cancer 12 years ago and received hormonal therapy is presented. Complex karyotypic abnormalities were present in the initial diagnosis phase The correlation between complex karyotypes and the prognosis in this case was discussed. Our 70 year-old patient was diagnosed as AML after peripheral blood and bone marrow analyses. His bone marrow cytogenetic analyses revealed 49, XY, -1, -2, +4, +6, +8, +8, -12, -13, der (1), +2 mar [3], 50, XY, -2, +4, +6, +8, +8, -13, +2mar [2], 50, XY, -2, +4, +6, +8, +11?, -13, +2 mar [1]. Complex karyotypes generally represents poor prognosis in AML cases. The patient died in two days after the initial diagnosis, although AML treatment was applied. As a result genetic examination should always be performed in elderly AML patients for both diagnosis and prediction of prognosis.

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Acute myeloid leukemia , karyotyping , chromosome aberrations , cytogenetics

Cumhuriyet Medical Journal

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