KAHRAMAN, Tahir Yüzüncü Yıl Üniversitesi - Eczacılık Fakültesi - Biyokimya Anabilim Dalı, Turkey , ÜSTÜN, Ramazan Yüzüncü Yıl Üniversitesi - Tıp Fakültesi - Fizyoloji Anabilim Dalı, ‎Turkey , BAYIROĞLU, Fahri Yüzüncü Yıl Üniversitesi - Veteriner Fakültesi - Fizyoloji Anabilim Dalı, Turkey , ASLAN, Recep Afyon Kocatepe Üniversitesi - Veteriner Fakültesi - Fizyoloji Anabilim Dalı, Turkey

The Effects of the Food Restriction on Lipid Peroxidation and Glutathione Levels in Rat Tissues

33137

Food restriction is known to decrease lipid peroxidation by causing reduced metabolic rate. During the oxygen metabolism in the body, lipid peroxidation end-products are generated. It is suggested that food restriction causes the enhancement of the antioxidant system. In this study, the alterations of malondialdehid which is one of the end-products of the lipid peroxidation and glutathione levels in the tissues liver, brain, testis, spleen, heart and kidney of the rats which exposed to the food restriction by 50 % during 8 weeks were investigasted. After the restriction period, even though the tissue MDA levels of the experimental group was found to be increased, this was not statistically important (p 0.05). As for the GSH levels of the study group, it tended to decrease in the liver, brain and kidneys but slightly increased in the testis tissue while there were no change in the spleen and heart tissues in respect of GSH levels. In spite of these alterations, it was not found statistical importance between the study and the control groups (p 0.05). It can be concluded that some adaptational changes such as slight increase in MDA levels and decrease in GSH levels started to take place in response of decreased protein and energy intake. But we think that the period of restriction was not enough to observe the drastical changes in these mentioned parameters in tissue levels.

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Tissue , Food Restriction , Malondialdehyde , Reduced Glutathione

Kocatepe Veterinary Journal

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