Author/Authors :
BİRDANE, Yavuz Osman Afyon Kocatepe Üniversitesi - Veteriner Fakültesi - Farmakoloji ve Toksikoloji Anabilim Dalı, Turkey , BİRDANE, Fatih Mehmet 2Afyon Kocatepe Üniversitesi İç Hastalıkları Anabilim Dalı, /TÜRKİYE - Veteriner Fakültesi, Turkey , ÖZDEMİR, Mehmet Afyon Kocatepe Üniversitesi - Veteriner Fakültesi - Farmakoloji ve Toksikoloji Anabilim Dalı, Turkey , KABU, Mustafa Afyon Kocatepe Üniversitesi - Veteriner Fakültesi - İç Hastalıkları Anabilim Dalı, Turkey , YAVUZ, Hidayet Afyon Kocatepe Üniversitesi - Veteriner Fakültesi - Farmakoloji ve Toksikoloji Anabilim Dalı, Turkey
Abstract :
Florfenicol a monofluorinated analogue of tiamphenicol, has antibacterial activity against a broad spectrum of bacterial strains, including enteric bacteria that are resistant to chloramphenicol and tiamphenicol. Pharmacokinetic parameters of florfenikol were determined in sheep after administration a sing intravenous (İV) doses 30 mg/kg body weight. Florfenicol concentrations in plasma were determined by a validated high-performance liquid chromatography (HPLC) methods with UV dedection at a wavelength of 223 nm. Blood samples were obtained at 5., 10., 15., 20., 30., 45. minutes ile 1., 1.5, 2., 3., 4., 6., 8., 10., 12., 14., 18., 24., 30. hours after injection. Plasma concentration–time data after iv administration were best described by a two –compartment open model. Concentrations of the drug in plasma were determined by HPLC. The pharmacokinetic parameters were as follows: elimination half life (t½β) was 3.34±0.25 hours, mean residence time (MRT) was 3.68 ±0.07 hours, mean volume of distribition at steady-state (Vdss) was. 0.97±0.07 kg/l, total body cleance (CL) 0.26 ±0.008 l/h/kg, area under curve (AUC) 113.13±3.45 μg.saat/ml after iv injections of 30 mg/kg doses weight.
