DEMİR, Hakan Afyon Kocatepe Üniversitesi - Veteriner Fakültesi - Farmakoloji ve Toksikoloji Anabilim Dalı, Turkey , BİRDANE, Yavuz Osman Afyon Kocatepe Üniversitesi - Veteriner Fakültesi - Farmakoloji ve Toksikoloji Anabilim Dalı, Turkey

Hepatotoxic Antibiotics

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Drug induced hepatotoxicity is one of the most important side effects in treatment. Liver is responsible for metabolism of many drugs and xenobiotics. Most drugs are lipophilic, enabling them to cross the membranes of intestinal cells. They gain a hydropylic structure through steps known as biotransformation by many enzyme systems in the liver. These transactions yields water soluble molecules and these are easily secreted in the urine or bile. Being the main organ of biotransformation, the liver is also the target organ for drug toxicity. The most handlig antibiotics in pediatric and geriatric clinical use are a big risc factor on hepatotoxiciy. Clinicians must be careful when using these antibiotics. Due to genetic polimorfizm of enzyme system, age, gender differences, infections, coexisting liver pathology and coadministered agents, different individuals exhibit different reactions to the same drug although given the same pharmacological doses. When liver injury exists, in the treatment the antibiyotics whose elimination has not been altered trough renal system should be chosen and the dose regulation should be done well.

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Antibiotic , Hepatotoxicity , Liver

Kocatepe Veterinary Journal

73