Author/Authors :
Altun, Özgüç Erciyes Üniversitesi - Tıp Fakültesi - Kadın Hastalıkları ve Doğum Anabilim Dalı, Turkey , Tayyar, Ahter Tanay Erciyes Üniversitesi - Tıp Fakültesi - Kadın Hastalıkları ve Doğum Anabilim Dalı, Turkey , Tayyar, Ahmet Niğde Doğan Baran Hastanesi - Kadın Hastalıkları ve Doğum Kliniği, Turkey , Özgün, Tuncay Erciyes Üniversitesi - Tıp Fakültesi - Kadın Hastalıkları ve Doğum Anabilim Dalı, Turkey , Öztürk, Figen Erciyes Üniversitesi - Tıp Fakültesi - Patoloji Anabilim Dalı, Turkey , Tayyar, Mehmet Erciyes Üniversitesi - Tıp Fakültesi - Kadın Hastalıkları ve Doğum Anabilim Dalı, Turkey
Abstract :
Aim. Previous studies proposed that low molecular weight heparin reduces postoperative adhesion formation. Octreotide reduces the maturation and migration of inflammatory cells by inhibiting insulin like growth factor via growth hormone. Some studies showed that octreotide also reduces postoperative adhesion formation. Low molecular weight heparin and octreotide influence different stages of adhesion formation. The aim of this study was to compare the effect of low molecular weight heparin and octreotide on postoperative adhesion formation either alone or in combination. Methods. The study included 40 Wistar Albino rats weighing between 250-300 g. They were randomised to three study and one control groups each containing 10 rats. After performing an adhesion model except for the control group, low molecular weight heparin, octreotide and low molecular weight heparin plus octreotide groups received the agents for14 days. The animals were sacrificed by lethal dose pentobarbital at the end of 14 days and a mid-line laparatomy was carried out and abdominal cavity was inspected for the presence of adhesion. Results. In macroscopic evaluation, adhesion severity in the 3 study groups were lower than the control group (p 0.05). Adhesion severity was lowest in the combined group (p 0.05). Adhesion extension score of the 3 study group was lower than the control group (p 0.05). But adhesion extension score of the combined group was similar with the octreotide and low molecular weight heparin groups (p 0.05). Microsopic adhesion score of the octreotide and the combined groups were lower than the control group (p 0.05). Conclusion. Octreotide and low molecular weight heparin are equally effective for prevention of adhesion formation. However, we suggest that combination of octreotide and low molecular weight heparin is more effective than the isolated use of either low molecular weight heparin or octreotide for prevention of adhesion severity.
