Erarslan, Elife Erarslan Etlik İhtisas Eğitim ve Araştırma Hastanesi - Gastroentereoloji Bölümü, Turkey , Yüksel, İlhami Dışkapı Yıldırım Beyazıt Teaching and Research Hospital - Department of Gastroenterology, Turkey , Haznedaroğlu, Serap Etlik İhtisas Eğitim ve Araştırma Hastanesi - Gastroentereoloji Bölümü, Turkey

The relation between colorectal carcinogenesis and metabolic syndrome

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Metabolic syndrome consists of a cluster of diseases including obesity, dyslipidemia, hyperglycemia and hypertension. Most of the components of metabolic syndrome have been associated with the development of neoplasm. The metabolic syndrome and visceral obesity have an increasing prevalence and incidence in the general population. Obesity has recently been linked to mortality in the majority of cancers. Colorectal cancer is an important public health problem. Recent reports in individuals with metabolic syndrome showed a high risk of colon or rectal cancer. The pathophysiological mechanism that links metabolic syndrome and colorectal cancer is mostly related to abdominal obesity and insulin resistance. A multidisciplinary approach involving nutrition, exercise, and stress reduction may be an opportunity to limit the insulin-resistant state and improve cancer outcomes.

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Metabolic syndrome , cancer , insulin resistance , obesity

Cumhuriyet Medical Journal

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